The Cell and Tissue Engineering Laboratory (CTEL) within the Children and Adolescent Cancer & Blood Disease Center at Westchester Medical Center consists of a 7,800 square foot, current good manufacturing practice (GMP) facility housing 7 Class 10,000 manufacturing suites.
CTEL provides the following services:
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- GMP clinical lab to perform cell separations, expansions, processings, cryopreservations and transductions
- QC/QA section for safety testing and audits
- two separate cell processing sections
- cell tissue culture area for cell/tissue expansion
- flow cytometry for sterile cell sorting
- cell culture for manufacturing specific cell types, like natural killer cells
- viral vector for vector production and transduction
Several processing suites contain “state of the art” equipment (such as the Miltenyi Prodigy and CliniMACS, Becton Dickinson Sterile Cell Sorter, and Lonza Nucleofector Device) intended to facilitate and enhance Cellular Therapy (CT) manufacture under human somatic cell therapy investigational new drug applications (INDs). Laboratory staff are dedicated to cellular therapy (CT) and hematopoietic progenitor cell (HPC) processing intended for transplant in the treatment of hematological malignancies and non-malignant diseases.